Genetic Polymorphism of TLR5 and TLP6 in Iraqi Patients with Heart Failure Disease

In spite of the high rate morbidity and mortality heart failure (HF) is common, none medications are now entirely available for HF treatment. addition to many environmental influences clinical diseases, genetic factors may also contribute progression development HF. current study, samples blood were collected from 150 patients 130 healthy controls. We evaluated association four single nucleotide polymorphisms (snps) Toll-like receptors (TLR6 TLR5) with susceptibility in Iraqi population. this work, (SNP) called receptor 5 (rs5744168, rs2072493) 6 (rs1039559, rs5743810) employed. (PCR-RFLP) snps rs2072493, re5743810), sequencing used assess allele genotype frequencies both patient control groups (rs1039559). controls, a significant difference was discovered genotypic allelic snps. From our results, we suggest that these act as potential predisposing factor development.